Squamous cell carcinomas of the head and neck
نویسندگان
چکیده
منابع مشابه
Squamous cell carcinomas of the head and neck.
Emerging knowledge on how the dysregulated function of signaling networks contributes to the malignant growth of squamous cell carcinoma of the head and neck (HNSCC) can now be exploited to identify novel mechanism-based anticancer treatments. In this regard, we have observed that persistent activation of the serine/threonine kinase Akt is a frequent event in HNSCC, and that blockade of its ups...
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OBJECTIVES To compare toxic effects and functional outcomes of reirradiation with and without salvage surgery for nonnasopharyngeal mucosal head and neck squamous cell carcinoma. DESIGN Retrospective review. SETTING Academic tertiary referral hospital. PATIENTS Between December 1992 and March 2007, a total of 87 patients underwent reirradiation (64 for cure and 23 for palliation). INTER...
متن کاملComprehensive MicroRNA profiling for head and neck squamous cell carcinomas.
PURPOSE The objective of this study is to investigate the significance of microRNAs (miRNA) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). EXPERIMENTAL DESIGN A global miRNA profiling was done on 51 formalin-fixed archival HNSCC samples using quantitative reverse transcription-PCR approach, correlated with patients' clinical parameters. Functional characteriz...
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Recent studies about solid tumors demonstrated that tumor microenvironment has an important role in tumor progression, aggressivity, and metastasis process, in addition to genetic aberrations and molecular alterations of cancer cells. Therefore, the crosstalks between cancerous and noncancerous cells and metabolic changes in tumor microenvironment cause significant detrimental effects. The purp...
متن کاملCetuximab in squamous cell head and neck carcinomas.
The epidermal growth factor receptor (EGFR) antagonist, cetuximab, has recently been shown to enhance the effects of radiotherapy, and reports to date indicate that this effect occurs without any change in the pattern and severity of toxicity usually associated with head and neck radiation and/or chemotherapy (CT) administration. Moreover, several studies have reported that the expression of EG...
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ژورنال
عنوان ژورنال: BMJ
سال: 2003
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.326.7383.282